Thank you for your participation in our first survey on prioritizing research topics in the field of pediatric oncology patients admitted to the Pediatric Intensive Care Unit (PICU).
We hereby invite you to share your opinion as an important stakeholder with regards to the research topics on pediatric cancer patients at the PICU.

We would highly appreciate it if you could fill out the following questionnaire, which should take about twenty minutes.

This survey is conducted on behalf of the POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC. POKER was founded in 2017 and has a mission to improve the care for and outcome of pediatric cancer patients admitted to PICU. As a first step, POKER aims to obtain consensus in determining the top research priorities in the field of pediatric cancer patients at the PICU for the next 10 years.
We established preliminary research topics based on review of the literature and expert opinion of the members of the POKER group. We would like to ask you to prioritize these research topics. In addition, we appreciate your suggestions upon any research topics that you think should be addressed in this research field.

All data will be evaluated anonymously and no personal data is collected. Your data will be stored on a secure university server and will only be used according to the Federal  Data Protection Act. All answers will be summarized and analyzed as a group.

Your participation is completely voluntary and you can withdraw at any time without giving a reason. Since all data is collected anonymously, it is no longer possible to access, change or delete data after the survey. If you are willing to participate, you will be asked to click on the approval box below.

If you have any questions or concerns, please do not hesitate to contact Roelie Wösten-van Asperen by email (r.m.vanasperen@umcutrecht.nl).

Thank you for your participation!


On behalf of all POKER members,

Roelie Wösten

POKER: Eva Tschiedel & Christian Dohna-Schwake (Universitätsklinik Essen, Germany), Jef Willems (Ghent University Hospital, Belgium), Frédéric Valla (Hôpital Universitaire Femme Mère Enfant, France), Jeppe Nielsen (Rigshospitalet, Copenhagen, Denmark), Jenny Potratz (University Hospital Münster, Germany), Martin Krause (Universitätsklinikum Schleswig-Holstein, Germany), Joe Brierley (Great Ormond Street Hospital for Children NHS Trust, UK), Martine van Grotel & Marry van den Heuvel-Eibrink (Princess Máxima Center for Pediatric Oncology, the Netherlands), Sjef van Gestel & Roelie Wösten-van Asperen (Wilhelmina Children's Hospital, the Netherlands)

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* 1. What is your gender?

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* 2. What is your age?

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* 3. Which position do you hold within your organization?
Please choose the answer that best describes your situation. 

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* 4. What is your country of practice?

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* 5. Please state the number of years in practice (PICU or oncology)

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* 6. How many beds does the PICU in your medical center provide?

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* 7. How many pediatric oncology patients are admitted to the PICU on an annual basis?

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* 8. How many new cases of pediatric cancer patients does your center admit on an annual basis?

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* 9. Does the oncology at your center provide allogeneic BMT?

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* 10. At what type of PICU do you work?

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* 11. Does the PICU at your center provide renal replacement therapy?

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* 12. Does the PICU at your center provide ECMO?

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* 13. Research topic 1: Development of specific early warning scores to timely recognize critically ill pediatric cancer patients on the non-ICU ward requiring intensive care support.

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* 14. Research topic 2: Epidemiology of pediatric cancer patients admitted to the PICU: prevalence and outcome.

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* 15. Research topic 3: Determine the role of non-invasive ventilation in acute respiratory insufficiency in critically ill pediatric cancer patients.

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* 16. Research topic 4: Determine the optimal timing of the use of life-sustaining therapies (mechanical ventilation, use of vasopressors, CRRT, and ECMO) in critically ill pediatric cancer patients.

There may be “golden hours or days” of resuscitation associated with improved outcome, for the management of critically ill cancer patients at the PICU. During this time, everything should be done. Subsequently, the continuation or introduction of life-sustaining therapies in patients whose conditions are worsening may not be beneficial. Observational studies are needed to
determine the optimal time for the “PICU Trial”, i.e. stratification of interventions by days of PICU treatment and outcome.

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* 17. Research topic 5: Exploring end-of-life care for children with cancer at the PICU, i.e. change to end-of-life care: medical consequences, communication with patients and parents.

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* 18. Research topic 6: Sepsis in critically ill pediatric cancer patients at the PICU: management, outcomes, and costs.

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* 19. Research topic 7: Determine the impact of critical illness and PICU admission on long-term outcomes.

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* 20. Research topic 8: Develop international standards for transfusion policies (red blood cell and/or platelets) in critically ill pediatric cancer patients.

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* 21. Research topic 9: Anti-infective strategies in pediatric cancer patients at the PICU (e. g. empiric antibiotic therapy, surveillance and treatment of invasive fungal diseases).

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* 22. Research topic 10: Nutritional aspects of cancer patients supportive care in PICU: Graft-versus-host disease, severe mucositis: enteral versus parenteral nutrition.

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* 23. Please suggest any research topics that you think should be addressed in the field of pediatric cancer patient admitted to the PICU.

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